Professor
Cincinnati Children's Hospital Medical Center, Ohio, United States
Anne Karina Perl serves as a Professor in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's Hospital Medical Center within the Department of Pediatrics at the University of Cincinnati. She is Faculty in the Center for Pulmonary Imaging Research, Developmental Biology, and the Center for Stem Cell & Organoid Medicine. She is Director for the Biomedical Research Technology Masters Program.
With a career spanning over two decades at Cincinnati Children's Hospital Medical Center, Dr. Perl has made significant contributions to the field of Pulmonary Biology and lung development. Her notable achievements include the development of lung-specific promoters regulated by doxycycline, which have been instrumental in advancing the study of lung biology through mouse models.
She has been a pioneer in employing lineage tracing techniques to distinguish genetic programs that differentiate conducting versus peripheral airway epithelial cells. She has also developed a model for the conditional expression of diphtheria toxin to induce epithelial injury, facilitating the study of lung progenitor cells. Moving away from her initial work with epithelial cells, she embarked on her independent research journey dedicated to lung fibroblasts and has established an international reputation in lung fibroblast biology research. Her primary research focus is to understand context dependent activation of alveolar fibroblasts and their role during lung development, aging, chronic disease, and regeneration. Her research employs various approaches to investigate the shifts in fibroblast function leading to activities such as contraction, extracellular matrix synthesis, and lipid biosynthesis. Her laboratory has introduced innovative mouse models to explore different fibroblast lineages, including myofibroblasts, matrix fibroblasts, and lipofibroblasts. Anne Karina Perl utilizes clinical lung tissue samples, patient-derived lung organoids, and transgenic mouse models to delve into the signaling networks that regulate fibroblast function and their interactions with epithelial cells.
Exploring Myo and Matrix Fibroblast Function and its Implications for BPD
Saturday, March 23, 2024
11:00am – 11:30am US EDT
