Professor and Chair
Yale University
New Haven, Connecticut, United States
Scott Holley is Chair and Professor of the Department of Molecular, Cellular and Developmental Biology at Yale University. He did his Ph.D. at the University of Chicago with Chip Ferguson where he demonstrated the conservation of dorsal-ventral patterning mechanisms between Drosophila and vertebrate embryos. He also discovered that noggin is a Bmp antagonist and elucidated the phenomena of facilitated diffusion in establishing signaling gradients. He was a Damon Runyon Postdoctoral Fellow with Nobel Laureate Christiane Nüsslein-Volhard at the Max Planck Institute for Developmental Biology in Tübingen, Germany. There, he discovered the zebrafish segmentation clock which establishes the segmental pattern of the spinal column. Genetic perturbation of the segmentation clock causes congenital scoliosis in zebrafish, mice and humans. His lab at Yale takes an interdisciplinary approach to studying early spinal column development in zebrafish. The overarching goal of his research is to use quantitative in vivo analysis to gain fundamental insights into the emergence of biological organization from the collective interaction of its constituent parts. His lab used systematic analysis of cell motion and single molecule biophysics of adhesion proteins to reveal roles for regulated tissue fluidity and inter-tissue adhesion in embryonic body elongation. In this presentation, he will present evidence for a Cadherin, Integrin and ECM code for tissue viscoelasticity.
The Biomechanics and Biophysics of Early Spinal Column Development
Saturday, March 23, 2024
2:15pm – 2:45pm US EDT
