Associate Professor
Harvard Medical School
Boston, Massachusetts, United States
Dr. Zheng-Yi Chen, is an associate professor of the Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School and Massachusetts Eye & Ear. His laboratory is focused on the development new treatment for human deafness. He obtained BSc from Sichuan University in China and his DPhil. in human genetics from Oxford University, UK. He did his postdoctoral fellowship at the Massachusetts General Hospital/Harvard Medical School.
The main focus of his laboratory is on the development of therapies based on genome editing, small molecules, AAV gene therapy, and mammalian inner ear regeneration for diverse forms of hearing loss, including genetic hearing loss, age-related and acquired hearing loss. His laboratory has been involved in the identification and characterization of numerous genetic deafness genes, in the creation of large animal pig models for human genetic hearing loss, and in the applications of gene editing to treat genetic hearing loss in animal models. They were involved in the first successful clinical trial of OTOF gene therapy to restore hearing in children with congenital deafness DFNB9. Another focus of his laboratory is to develop novel delivery vehicles for editing agents in the inner ear for therapeutic application in human patients.
Reprogramming by Drug-Like Molecules in Hair Cell Regeneration in the Mature Inner Ear
Sunday, March 24, 2024
9:00am – 9:30am US EDT
